Week 168: radiation and off to Singapore

Written by Lars Haakon Soraas
11
Nov

Week 168 in the war on lung cancer has passed. Here are the highlights:

  • Dyanne received the planned radiation to the lymph node conglomerate in the right hilum in the lungs and another lesion in the left lung.
  • Dyanne has been in pretty good shape the whole week.
  • We have gotten some initial results from the biopsy that was done from the lymph node conglomerate in the right hilum of the lungs. The results are from the hospital here in Oslo and the testing done is quite limited. More comprehensive results will be obtained from the analysis done by Cegat GmbH. In any case, here in Oslo they have not found any targetable mutations in EGFR (apart from the known exon 19 deletion), BRAF, ROS1, ALK and MET. They have, however, found a significant level of CEA expression and also a quite high level of MUC1 (also called CA15.3) expression. None of these can be targeted easily today, but both CEA and MUC1 are currently explored as targets in clinical trials. At the bottom of this post are some of the microscope images of the biopsy specimen.

We are, needless to say, anxious to see how the tumor marker CEA develops now after the radiation. We hope it will drop fast. Time will show.

We are going to Singapore this week and will stay until early December. If there are any EGFR mutant lung cancer patients there who would like to meet up, then please do reach out to me. While in Singapore, I will also go to ESMO Asia, a cancer research conference that takes place while we are there (23-25th November). If anyone else is going there, then please let me know and we can meet up.

Hope everyone has had a good weekend!

Spot the cancer cells. Hint: they are non-small.

Biopsy under the microscope: brown is CEA.

Biopsy under the microscope: brown is MUC1 (CA15.3).

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