Weeks 198 & 199: time for chemo again

Written by Lars Haakon Soraas
16
Jun

Weeks 198 and 199 in the war on lung cancer have passed. Here are the highlights:

  • As described in the previous post, we decided to try a combination of auranofin, disulfiram and a couple of other drugs. We measured tumor markers before and after starting this combo and, unfortunately, there were no signs it had any effect. We thus decided to discontinue this combination.
  • Tumor markers have risen sharply lately, indicating progression of the cancer. Dyanne did a PET-CT scan last week and this confirmed that there were progression in multiple places.
  • Based on the progression, and our unsuccessful attempts to curb it with various drug combinations, we went back to our fall-back plan, which was another round of chemotherapy (carboplatin and etoposide). Dyanne got another infusion of chemo last week.
  • We have done one measurement of the tumor markers CEA and NSE after the chemo infusion. And, luckily, they have fallen. The charts are pasted in at the end of this blog post.

In other news, Dyanne has broken her arm. She fell while out walking. The reason is simply her somewhat impaired balance, which is due to a brain met that was treated with stereotactic radiation in 2016 and then by surgery in 2017.

In yet other news, we decided to go to a wedding in Italy. We had initially cancelled it due to the broken arm and the fact Dyanne had to get chemo a couple of days before the wedding. However, Dyanne felt surprisingly well after the chemo and we decided to go anyway. Attached is a picture from the wedding.

Finally, we have recently spent some time looking into fever inducing therapies. The first “modern” immunotherapy treatment was, in fact, a fever inducing bacteria that was employed by a US doctor named William Coley some 100 years ago in New York. For a nice introduction to his work, this podcast is good:
https://www.peoplespharmacy.com/2019/01/31/show-1151-what-was-the-first-immunotherapy-for-cancer/.

Hope everyone has had a good week!

At wedding in Italy
Dyanne with broken hand and a cast
CEA: red markers show when chemo was given; orange marker shows start of auranofin++

NSE: red markers show when chemo was given; orange marker shows start of auranofin++

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